High-fat diet intake and jaboticaba peel extract effects in the prostatic adenocarcinoma model: Protective action in the metabolic disorders and liver histopathology

Prostate cancer (PCa) and obesity are significant worldwide health problems, which are associated with world mortality increase. Clinical studies have shown that high-fat diet consumption is associated to higher incidence of the PCa. Brazilian berries, such as Myrciaria jaboticaba (Vell.) Berg, present high polyphenol concentration in the peel and display positive effects on hyperinsulinemia, oxidative stress and hepatic disorder balance. Therefore, the aim of study herein was to investigate the patented jaboticaba peel extract (PJE) effects on different metabolic parameters and liver histopathology in the transgenic adenocarcinoma of the mouse prostate (TRAMP) model, receiving either standard diet or high-fat diet. Eight-week-old mice were randomly distributed into the following groups (n=5): C group fed with standard diet and treated with vehicle; JC group fed with standard diet and treated with PJE; H group fed with HFD and treated with vehicle; JH: group fed with HFD and treated with PJE. The PJE treated groups received (5.8g PJE /kg body weight) and the vehicle was water. After experimental period, the TRAMP mice were euthanized and the liver samples were collected for morphology evaluation, lipid profile and western blotting analysis. The plasma obtained was used to lipid profile and glucose level analysis. The results showed that PJE reduced insulin resistance and glucose intolerance, hepatic lipid accumulation and lipidic metabolism markers such as PPARγ and TNFα. In conclusion, the PJE treatment promoted protective effects in insulin and glucose metabolism and liver imbalance caused by HFD intake in the PCa model, suggesting that it may be a good protector against metabolic disorders present in overweight associated with PCa.