Physical Exercise Activates Purinergic System via P2X7 Receptor and Improves the Gastric Emptying Delay Induced by Cisplatin in Rats

Chemotherapy drugs such as cisplatin can cause autonomic dysfunction, and effects such as nausea, vomiting, diarrhea, and constipation that lead to gastrointestinal dysmotility. Recently our group showed that cisplatin alters gastrointestinal motility, and this effect may be prevented with anticholinesterase inhibition. In another hand, we suggest that physical exercise and purinergic signaling can be involved in these changes in the gastrointestinal tract.