Exploring the effects of ayahuasca on Conditioned Place Aversion memory in Zebrafish models

Ayahuasca, an indigenous brew made from the combined infusion of Banisteriopsis caapi (rich in monoamine oxidase inhibitors (MAOi) such as harmine), and Psychotria viridis (rich in N,N-dimethyltryptamine or DMT), has stood out as a new treatment for mnemonic deficits associated with depression. The single use of the brew is also associated with long-term effects on behavior in several animal species. Here, we tested if DMT and harmine in a chronic administration protocol could exert a pharmacologic role on long -term memory using a zebrafish animal model.