White adipose tissue morphology: comparative analysis of automated segmentation methods

Obesity is associated with morphological changes in white adipose tissue. Previous studies in rodents and humans indicated that increased adipocyte area is related to the development of metabolic disorders. Given the strong association between adipocyte hypertrophy and obesity-related comorbidities, it is crucial to assess the accuracy of existing measurement methods. In this study, we aimed to compare automated softwares in order to provide a more reliable method and accurate data analysis of white adipose tissue morphology.