Vitamin d deficiency effects on the evolution of gentamicin-induced kidney injury

Gentamicin (Genta) is one of the most effective antibiotics used the treatment of the infection caused by gram-negative bacteria. However, despite its efficacy, it has a nephrotoxic effect characterized by acute tubular necrosis (ATN) in the proximal tubular cells of the kidneys, that leads to an acute kidney injury (AKI). Vitamin D deficiency (25(OH)D <20ng/mL) can exacerbate the inflammatory process, the oxidative stress and the renal tubular cell injury, which are important events that can contribute to the alterations in renal function and structure caused by Genta.