Vascular effects of acute fructose overload in sham and ovariectomized rats

Fructose is a monosaccharide with greater sweetening power than sucrose and its chronic excessive consumption has been associated with vascular alterations, a worrying fact due to the exacerbated increase in the intake of this sugar in recent decades, mainly with the introduction of high fructose corn syrup by the food industry. The absorption and metabolism of fructose differs from glucose and is not subject to the same regulatory mechanisms, so fructose can be used as a substrate for de novo lipogenesis, a factor that contributes to the increase in lipid fractions that is associated with the development of cardiovascular diseases. Although studies of chronic fructose consumption are well researched, the short-term effects of high fructose consumption have not yet been fully clarified.