USING ACRIDINE DERIVATIVES TO ASSESS THE INTRACELLULAR REDOX ENVIRONMENT AND CELL VIABILITY OF S. cerevisiae STRAINS CONTAINING BETA-AMYLOID PEPTIDE

Alzheimer’s is a neuropathology that affects millions of people Around the world. Currently, there is no known treatment capable of curing or stopping the progression of this disease. Due to this, the Search for new therapeutic alternatives is essential. A promising target for new anti-Alzheimer’s compounds is the multifactorial aspect of the disease. In addition to beta-amyloid peptide aggregation, oxidative stress, reduced acetylcholine levels and neurofibrillary tangles are disorders triggered by this pathology. For this reason, acridine acetylcholinesterase inhibitors have also been studied for their antioxidant potential and anti-amyloid toxicity.