Title: CHANGED INTESTINAL PERMEABILITY IN A MODEL OF ALCOHOLIC LIVER DISEASE IN ADULT ZEBRAFISH. Diglio, D.C.1,2, Salau, E.H.2, Schneider, A.C.R.1,3, Furtado-Filho, O.V.1,2, Silveira, T.R.1,3, Porawski, M.1,2 . 1Laboratório de Fisiologia Comportamental e Metabólica daUniversidade Federal de Ciências da Saúde de Porto Alegre; 2Programa de Pós-Graduação em Biociências e 3Programa de Pós-Graduação em Pediatria, Universidade Federal de Ciências da Saúde de Porto Alegre, RS

Introduction: Alcoholic liver disease (ALD) caused by alcohol abuse is among the leading causes of death worldwide. Zebrafish are a suitable model for studying alcoholic disease because they tolerate constant exposure to ethanol in aquarium water. Despite differences in the anatomical architecture of the liver in zebrafish and mammals, liver damage is similar to that found in humans, as are the characteristics of the intestinal epithelium. Integrity of the intestinal epithelium is determined mainly by tight junctions (TJ), a selectively permeable protein complex, among which we can highlight junctional adhesion molecules (JAM) and claudins.