TIME-DEPENDENT MODULATION OF CARDIOMYOCYTE CONTRACTILITY BY ALAMANDINE.; Monteiro, A.L.L., Scalzo, S.R.A., Inacio, M.E.S., Silva, M.M., Sanches, B.L., Santos, A.K., Ferreira. K.K.S., Santos, R.A.S., Rodrigo A. Peliciari-Garcia, R.A., Cau, S.B.A, Guatimosim, S., Department of Physiology and Biophysics, Institute of Biological Sciences, UFMG, Belo Horizonte, Minas Gerais.

Alamandine (ALA), a Renin-angiotensin-system (RAS) cardioprotective peptide was described as a positive modulator of cardiomyocyte (CM) contractility from a model of hypertensive disease. Whether this modulation is susceptible to temporal variations is yet to be described, even though the circadian variation is an important pattern observed in the cardiovascular system, and by members of the RAS.