The treatment with progesterone prevents deleterious effects on the endothelium caused by hormonal deficiency in ovariectomized rats

Introduction: Progesterone (P4) is a steroid hormone produced by the ovaries, placenta and adrenal glands, essential for reproduction. In addition, P4 can act directly on the endothelium and vascular smooth muscle, via specific receptors, being considered important for vascular homeostasis. Although P4 has a beneficial effect on the cardiovascular system, P4 actions on the coronary bed have not yet been fully elucidated.