The nitric oxide synthase (NOS) inhibition can promote metabolic changes associated with foetal growth restriction in pregnant mice

Pregnancy promotes extreme changes in the female`s physiology. Disorders such as preeclampsia (PE) can occur with an imbalance of several factors, which leads to hypertension, proteinuria and/or target organ dysfunction, culminating in foetal growth restriction. It affects around 5% of pregnancies in the poorest regions worldwide. A classical preclinical model of preeclampsia is the pharmacological inhibition of NOS over pregnancy. However, the metabolic consequences of this treatment are still to be further studied.