The expression of Cholesteryl Ester Transfer Protein (CETP) in the perivascular adipose tissue results in contrasting effects between sexes.

The cholesteryl ester transfer protein (CETP) transfers cholesterol from HDL to VLDL/LDL, thereby reducing HDL-cholesterol, a widely recognized athero-protective lipoprotein. Current evidence suggests that the metabolic effects of CETP may vary according to sex and tissue. As the vascular protective effect of perivascular adipose tissue (PVAT) is sex-dependent, we hypothesized that there is sexual dimorphism on the CETP impact on the PVAT function.