The Effect of Nanosystems on ATP-Binding Cassette Transporter

Cancer multidrug resistance is involved in the failure of various treatments during cancer therapy. This phenomenon has received much attention due to the number of recently discovered mechanisms involved in the process of cancer resistance. Among these mechanisms, the involvement of the ABC (ATP-binding casette) system transporters has been shown to be the main one. The ABC system transporters are a group involved in the process of clearing substrates from the cell, which are usually over-expressed in cancer. This clearance goes beyond metabolites and involves other molecules as well, affecting drug absorption, distribution and metabolism. In this study, we evaluate the influence of three nanosystems: graphene quantum dots (GQDs), mesoporous silica (MSN) and polylactic nanoparticles (PLA) on this main mechanism of multidrug resistance in cancer.