THE CONTRIBUTION OF EXTRACELLULAR VESICLES RELEASED BY PREADIPOCYTES TREATED WITH CONDITIONED MEDIUM FROM OBESE ADIPOSE TISSUE ON THE TUMOR METABOLISM OF MDA-MB-231 CELLS. Botelho, L.G.X.#, Ramos I.R&., Barja-Fidalgo, C#&, Renovato-Martins, M#. *Laboratório de Inflamação e Metabolismo, IB, UFF, Niterói. #Programa de Pós-Graduação em Biociências, UERJ, Rio de Janeiro. &Laboratório de Farmacologia Celular e Molecular, UERJ.

Obesity is a growing worldwide public health problem characterized by excessive accumulation of body fat, induction of a low-grade chronic inflammatory condition, and association with several other diseases, such as cancer. This abnormal accumulation of fat affects the morphophysiology of adipose tissue (AT), including the secretion levels of extracellular vesicles (EVs). EVs are essential structures for extracellular communication. There is a strong relationship between obesity and a worse prognosis for breast cancer, and it is also known that EV released by obese AT can alter the tumor microenvironment. Still, a factor as important as unknown is metabolic cooperation between preadipocytes and tumor cells in obesity, especially the role of fatty acid oxidation.