SYSTEMIC DENGUE VIRUS INFECTION INDUCES ACUTE NEUROINFLAMMATION THAT COUNTERACTS ZIKA VIRUS DISEASE IN A129 MICE.

Arboviruses are significant infectious diseases that affect tropical and subtropical regions worldwide, carrying the risk of severe complications and even death. The recent outbreak of the Zika virus (ZIKV) in Brazil shed light on the extensive impact of this virus on the central nervous system (CNS), resulting in neuronal death and associated neuroinflammation. Similarly, a few studies have demonstrated that the Dengue virus (DENV), an antigenically similar virus, is also linked to cases of encephalitis. However, the precise mechanisms through which DENV infects the brain and affects its function, as well as the long-term neurological consequences, remain unknown.