Subacute inosine administration restores endothelial dysfunction and inflammation in a hypercholesterolemic model

Atherosclerosis is characterized as a chronic process closely related to inflammatory and proliferative responses of the endothelium after injury. Inosine, an analog of adenosine, results of adenosine deamination by adenosine deaminase. Adenosine and its analogs can change a variety of inflammatory diseases mediated by the immune system and have shown important effects at different models.