Study on the Participation of the Adrenergic System in the Modulation of Peripheral Pain

Noradrenaline is classic involved in endogenous modulation of pain at the spinal site. On the other hand, noradrenaline is also involved in the peripheral inflammatory pain and analgesia by a different mechanism. The adrenergic system during installation of neuropathy increase α2A receptors expression and α2C in nerve large and medium damage, and also decrease α2C receptors concentration in nerve small damage, in addition to increase in the effectiveness of α2 adrenergic receptors coupled to G protein. Therefore, this study proposed to investigate the involvement of the noradrenergic system in the peripheral modulation of inflammatory pain.