STUDY OF THE MOLECULAR VARIATION BETWEEN THE ISOLATED AND SEQUENCED GENOMES OF SARS-CoV-2 IN THE MUNICIPALITIES OF MACAÉ-RJ AND THE REGION

Coronavirus is a positive, enveloped, single-stranded RNA genome virus (26 to 32 kb) belonging to the Coronaviridae family and the Nidovirales order. SARS-CoV-2 virus primarily affects the respiratory system, although other organ systems are also involved. The emergence of new variants of SARS-CoV-2 harboring mutations in the Spike (S) protein, the protein responsible for infection and interaction with angiotensin-converting enzyme 2 (ACE2) receptors in human cells, may affect its transmissibility, being matter of great concern. Studies indicate that the pan-genomic analysis of global isolates of SARS-CoV-2 has identified numerous genomic regions with greater genetic variation and distinct mutational patterns.