SPHINGOSINE-1-PHOSPHATE, CXCL12 AND INTEGRIN INTERACTIONS IN NEOPLASTIC T-LYMPHOCYTE MIGRATION

T-cell lymphoblastic leukemia/lymphoma (T-LLL) results from malignantproliferations of T precursors that exhibit phenotypic characteristics similar to distinct stages of normal T cell maturation. It is described that sphingosine-1-phosphate (S1P) and CXCL12 can modulate interactions mediated by integrins, which are essential for the migration of T cell precursors in physiological and pathological conditions. Furthermore, data from our group, obtained with human T-ALL lines, suggest that interactions mediated by the sphingosine-1-phosphate receptor 1 (S1P1) are related to the migratory behavior of the blasts.