Sodium alginate and nanocellulose hydrogel as scaffold to in vitro 3D prostate cancer irradiated model.

Recently, traditional cell culture systems structured in 2 dimensions using monolayers of cells in culture media are being replaced by 3D structures, in which cells can be organized in spheroids. To obtain these structures, hydrogels can be used as permeable to gas and nutrients scaffolds, also providing physical support to cells. This work aimed to produce a double network hydrogel containing sodium alginate (SA) and nanocellulose (NC), obtained by irradiation of microcrystalline cellulose, and its ability to maintain in culture of human prostate adenocarcinoma.