Profile of muscle loss and and functional parameters during the progression of cachexia induced by colorectal carcinoma CT26.WT

Cachexia is a multifactorial and complex syndrome present in chronic inflammatory diseases such as cancer. It is often associated with declining in physical function and quality of life. Several phenomena are involved in the pathophysiology of cachexia, including metabolic, inflammatory, and oxidative stress. It is known that decreased food intake, as well as the formation of reactive oxygen species positively regulate protein degradation pathways and muscle atrophy, that directly interferes with the life expectancy of patients.