Prenatal Stress Induces Long‑Term Behavioral Sex‑Dependent Changes in Rats Offspring: the Role of the HPA Axis and Epigenetics

Stressors periods during pregnancy could impact the offspring’s well-being until adulthood, increasing its predisposition to diseases and mental disorders. In addition, early exposures to stress have been related with changes in hypothalamus-pituitary-adrenal (HPA) axis function and epigenetic mechanisms. However, more evidence about the long-term impacts of prenatal stress exposure in behavioral and epigenetic profile of offspring are necessary