Phenotypical aspects of NAFLD-associated hepatocarcinogenesis model in mice

Epidemiological findings show that hepatocellular carcinoma (HCC) features as the 6th/3rd most incident/deadliest type of cancer, also establishing a clear interplay non-alcoholic fatty liver disease (NAFLD) and its associated comorbidities. In this context, adherence to a westernized diet (WD) has been prospected as a driver of NAFLD, affecting both hepatic and adipose tissue (AT), and increasing the risk for HCC. Nevertheless, a translational murine model the resembles the main phenotypical aspects of the corresponding human disease is still needed.