Phenotypes and functions of prostatic intraepithelial macrophages: effects of castration

Androgens are important for prostate gland development and homeostasis. Androgen deprivation leads to the influx of immune cells, in particular, of different populations of macrophages. We have shown tha prostatic epithelial cells cultured in the absence of androgenic stimulus induced to the production of soluble factors tha influence macrophage polarization and motility. Futhermore, LNCaP conditioned medium affects macrophages RAW 264.7 cells promoted prostate epithelial cell death (J Cell Physiol 2019).