NEONATAL OVERFEEDING INDUCES BROWN ADIPOSE TISSUE HYPERPLASIA AND AMELIORATES INSULIN RESISTANCE INDUCED BY HIGH SUGAR DIET IN YOUNG RATS

Introduction: Adaptive thermogenesis is involved in the modulation of metabolic diseases, since brown adipose tissue (BAT) adipocytes produce heat both by oxidation of their fatty acids (FFA) and circulating FFA and glucose, contributing to improvement in insulin resistance (IR) conditions. However, the effects of neonatal overfeeding on BAT metabolism are still controversial. Therefore, establishing the mechanisms of IR correlated with neonatal overfeeding in BAT is crucial as a therapeutic target for metabolic diseases.