MTORC2 DEFICIENCY IN MYELOID CELLS IMPAIRS GLUCOSE METABOLISM WITHOUT AFFECTING HEPATIC INFLAMMATION

Nonalcoholic fatty liver disease (NAFLD) is a group of conditions that comprises from a simple steatosis (NAFL) and to more serious and life-threatening nonalcoholic steatohepatitis (NASH), cirrhosis and hepatocarcinoma cellular (HCC). Resident and infiltrated macrophages contribute to hepatic inflammation and progression from steatosis to NASH and HCC. mTORC2 and AKT are activated in macrophages by growth factors and proinflammatory mediators and counteract proinflammatory signaling.