Molecular Mechanisms Involved in the Control of Hepatic Gluconeogenesis in High Protein Diet Adapted Mice

Hepatic gluconeogenesis is vital for glycemia maintenance in different physiological situations. Previous studies from our laboratory have demonstrated that high protein (HP) adapted rats have low insulinemia concomitant with increased plasma levels of glucagon and corticosterone, which can be responsible for the high and constant hepatic gluconeogenesis found in these animals. However, it remains unknown the molecular mechanisms involved in the control of hepatic gluconeogenesis in animals adapted to the HP diet.