Mild behavioral impairment and amyloid-β accumulation in the amygdala precede cognitive decline in juvenile male 3xTg-AD mice

Neuropsychiatric symptoms can occur as equally important Alzheimer’s disease (AD) manifestations and at pre-dementia stages are referred to as mild behavioral impairment (MBI). Studying neuropsychiatric symptoms in earlier life may be an opportunity to investigate MCI as a potential marker for incipient cognitive decline in AD.