METABOLIC IMPRINTING INDUCED BY NEONATAL OVERFEEDING ALTER CATALASE ACTIVITY IN YOUNG RATS WITH INSULIN RESISTANCE

The postnatal period is able to predict or protect against diseases in adulthood, and this phenomenon is called metabolic imprinting (MI). High simple carbohydrates intake in childhood is related to weight gain and insulin resistance (IR) later in life, while breastfeeding is able to prevent them. In addition, IR can increase the reactive oxygen species (ROS) production, which can lead to oxidative stress (OE). Among the enzymes that make up the antioxidant system, catalase performs the function of breaking down hydrogen peroxide into water, reducing or eliminating potential damage to the body. IR is expected to increase EO and MI to alter the activity of the antioxidant system modulating oxidative damage in the animals after 8 weeks.