MENTHOL INDUCES RELAXATION IN CORPUS CAVERNOSUM FROM LEAN AND DB/DB MICE: COULD MENTHOL IMPROVE DIABETIC ERECTILE DYSFUNCTION?

Erectile dysfunction (ED) is a common complication of diabetes mellitus, and also an indicator for future cardiovascular events. In addition, menthol (classical TRPM8 agonist) is widely used to improve sexual performance, but with no studies reporting improvement in diabetic-ED. So, we hypothesized that TRPM8 channels activation could be a therapeutic target for the treatment of ED in diabetic mice.