IRX3 MODULATION IMPROVES FUNCTIONAL AND CONTRACTILE MATURATION OF HUMAN iPSC-DERIVED CARDIOMYOCYTESocytes

The Iroquois homeobox (Irx) family of transcription factors is involved in early cardiogenesis, but their specific effects on determining cardiac subtypes are not fully understood. Loss of Irx3 impairs the maturation of ventricular conduction in mice. Thus, we hypothesize that Irx3 can be modulated to alter the balance of cardiomyocytes’ (CMs) specialization towards the ventricular working phenotype.