Intranasal oxytocin exposure affects nicotine reward effects in an age-dependent manner.

Despite the reduction in tobacco consumption, a significant increase in e-cigarette use by adolescents has been observed over the last decade. Nicotine induces a powerful addiction and the rate of successful quit attempts is still low. The neuropeptide oxytocin (OXT) has been shown to influence the mesocorticolimbic system associated with the rewarding properties of drugs of abuse.