Inositol 1,4,5-triphosphate receptor type 1 modulates neuroinflammation in a autosomal recessive RP model

Retinitis pigmentosa (RP) is a disease that leads to a progressive loss of vision. Although the rod cell death pathway is well elucidated, the process that leads to cone cell death is not well known, hypotheses include an involvement of cytoplasmic and mitochondrial calcium excitotoxicity. Therefore, type 1 inositol-1,4,5-triphosphate receptor (IP3R1), a well-described calcium receptor widely expressed in neuronal cells and responsible for intracellular calcium homeostasis through depletion of calcium stored in the endoplasmic reticulum, might influence the progression of the disease.