INFLUENCE OF THE MYELOID DIFFERENTIATION FACTOR 88 KNOCKOUT ON EPILEPTIFORM ACTIVITY IN MICE

Epilepsy is a critical neurological condition marked by non-evoked seizures posing a significant threat to life. In recent years emerging research has shown an important role of myeloid differentiation factor 88 (MyD88), which is a pivotal neuroinflammatory protein, in the pathogenesis of status epilepticus. This study sought to explore the consequences of MyD88 knockout on the severity and duration of seizures, while also assessing its influence on survival. By understanding the impact of MyD88 in this context, we can comprehend valuable insights into the underlying mechanisms and potentially identify novel therapeutic targets for this debilitating condition.