INCREASED VASCULAR REACTIVITY AND PERIVASCULAR ADIPOSE TISSUE (PVAT) INFLAMMATION PROMOTED BY EXPOSURE TO COPPER IN DIABETIC AND NON-DIABETIC ANIMALS

Exposure to copper metal is directly related to cardiovascular and metabolic damage. When associated with other metabolic diseases, such as Diabetes Mellitus, this damage seems to get worse. On the other hand, a healthy perivascular adipose tissue (PVAT) has been recognized for its role in modulating vascular tone, through mechanisms that involve the release of vasodilator factors.