IMPACT OF DIETARY CITRATE ON COLONIC PHYSIOLOGY OVER TIME - COMPARISON BETWEEN ACUTE AND PROLONGED EXPOSITION

Metabolic diseases such as obesity and type 2 diabetes have been correlated to a disrupted microbiota and intestinal dysbiosis. Among the colon`s physiological function during digestive process, dietary patterns and some nutritional components already demonstrate deleterious effects at colon functioning, participating in inflammation, altered permeability and microbiota modulation. Some studies have already demonstrated the effect of food additives, very common in the current diet, on metabolic dysregulation. Among them, the negative effect of dietary citrate has already been observed on glycemic homeostasis and on adipose and hepatic tissue. However, the link between citrate and intestinal dysfunction has not been established.