HYPOTHYROIDISM MODULATES FASTING-INDUCED MITOCHONDRIAL DYNAMICS IN THE HEART OF MALE RATS

Thyroid hormones play a crucial role in the regulation of heart function and hypothyroidism has been related to increased mortality from cardiovascular diseases. Cardiac contraction rely on high levels of ATP, requiring healthy and efficient mitochondria to meet its energy demand. Optimal mitochondrial function is maintained by a balance between fusion and fission processes, associated with the effective elimination of injured mitochondria through autophagy. Disruption in mitochondria dynamics and autophagy is related to many pathological conditions, including cardiac disorders.