Eplingiella fruticosa leaf essential oil complexed with β-cyclodextrin exerts a neuroprotective effect in an Alzheimer’s disease animal model induced by streptozotocin

Alzheimer’s Disease (AD) is the most common cause of dementia. As a multifactorial disease, many pathological processes are implicated in its physiopathology, such as an increase in beta-amyloid peptide (Aβ) and hyperphosphorylation tau protein levels, neuroinflammation and oxidative stress. In the last two years, two disease-modifying drugs, i.e. Aducanumab and Lecanumab, were approved for the treatment of AD, but there is still concern regarding their safety and longtime effects, which indicates that novel drugs for AD treatment are still needed. In this context, plant extracts, such as Eplingiella fruticosa (EF) have shown neuroprotective effects in the treatment of neurodegenerative diseases, especially with the aid of animal models, such as the AD animal model induced by streptozotocin (STZ).