Endurance training in a hot environment reduces FoxO1 content, induces a muscle oxidative phenotype, and improves performance similar to temperate

Heat (H; ≥25°C) stress acutely worsens aerobic performance and short- and medium-term heat acclimations (< 3weeks) lead to several physiological adaptations that improve physical performance. H has also emerged as a potential therapy to modulate muscle metabolism inducing oxidative phenotype, but it is unknown the effects of endurance training (ET) on skeletal muscle in H environment for longer periods (> 4weeks).