ENDOTOXEMIA IN ANIMALS SUBMITTED TO MECHANICAL VENTILATION PROMOTES DIAPHRAGMATIC DYSFUNCTION

Mechanical ventilation (MV) and sepsis are important risk factors for diaphragmatic dysfunction in critically ill patients. MV is an auxiliary tool for breathing in critical patients, but as a non-physiological process it may result in damage to several organs, including the diaphragm muscle. Ventilator-induced diaphragmatic dysfunction (VIDD) is a frequent complication of MV, which results in difficulties in weaning from the ventilator and worse clinical outcomes. Sepsis is a dysregulated immune response to infection, that leads to diaphragmatic dysfunction.