EFFECTS OF TNFR1 KNOCKOUT IN TYPE 1 DIABETES MOUSE MODEL

Long-term type 1 diabetes mellitus (DM1) can lead to cognitive impairment. The streptozotocin (STZ)-induced DM1 model replicates several symptoms observed in humans, including cognitive deficits. Neuroinflammation associated with hyperglycemia has been suggested as a contributing factor to the observed cognitive impairments. TNF receptor signaling plays an important role in maintaining synaptic transmission homeostasis, but during neuroinflammation increased TNF concentration promotes synaptic impairment, particularly via TNFR1 in the hippocampus.