Effects of sitagliptin on mitochondrial and glycemic remodeling in spontaneously hypertensive rats fed a high-fat diet

Arterial hypertension and dyslipidemia are known and synergistic risk factors for the development of cardiovascular diseases, and adequate control of both factors is important to reduce morbidity and mortality. The aging process, diabetes and arterial hypertension are conditions that affect mitochondrial biogenesis, leading to a decrease in bioenergetics, and consequently in metabolism.