Effects of Carbetocin administration on behavioral sensitization to ethanol and glucocorticoid receptors in female and male Swiss mice

Substance use disorder is a complex condition influenced by genetic, environmental, and social factors. It is characterized by compulsive drug use, loss of control, and continued use despite negative consequences. Oxytocin (OT), a pro-social peptide, has emerged as a potential protective factor against drug addiction. OT has been found to modulate the activity of the hypothalamic-pituitary-adrenal (HPA) axis, which plays a crucial role in regulating glucocorticoid release.