EFFECT OF REPEATED INTRAPERITONEAL MESENCHYMAL STEM CELL INJECTIONS IN A MODEL OF COMPRESSIVE SPINAL CORD INJURY IN MICE

Traumatic spinal cord injury (SCI) causes motor and sensory deficits, due to the death of neurons, glial cells and demyelination. Despite advances in technology and rehabilitation, no effective therapies are available for patients with SCI, which remains a major medical challenge. Cell therapy, using several lineages of stem cells, has been considered a treatment with potential for functional repair after spinal cord injury. Although several studies use different models of spinal cord injury with different types of cell therapy, it is important to emphasize that questions regarding the best route of administration, the best dose of stem cells to be administered, or even the benefit that the administration of repeated doses can bring to the hostile environment that is established after spinal cord injury, are doubts that are part of the range of questions that still lack some answers.