EFFECT OF EXTRACELLULAR VESICLES DERIVED FROM TUMOR-ASSOCIATED NEUTROPHILS ON MDA-MB-231 CELLS

Breast cancer is the second most common type of cancer in the world and the first most common among women. It is well established the relationship between cancer and inflammation, and neutrophil infiltration has been described in tumors since 1863. Immune system cells, including neutrophils, are recruited by the tumor microenvironment and begin to favor tumor growth. The neutrophils present in the tumor site are called tumor-associated neutrophils (TAN) and can present 2 phenotypes: N1 (antitumor) or N2 (protumor). As an in vitro polarization strategy for N2 TAN, we use extracellular vesicles (EVs) derived from breast tumor cells (MDA-MB-231).