Effect of chloroquine treatment during pregnancy rats on cardiovascular function of offspring

The DOHaD theory postulates that exposure to adversity early stages of life can lead to the development of disease in adulthood. Chloroquine (CQ) is used during pregnancy and can cause cardiotoxic effects with cumulative doses administration. Although CQ is generally considered safe during pregnancy, its use in pregnancy is still subject to debate, especially since CQ crosses the placenta and can be deposited in fetal tissues.