Compensatory reduction in spontaneous physical activity in response to exercise in adult mice: effects of volume, intensity, and training status.

The most used strategy to increase daily energy expenditure is physical exercise. However, exercise provokes an energy homeostasis disruption which can trigger compensatory mechanisms that decrease everyday physical activity, also known as spontaneous physical activity (SPA). The reduction in SPA lessens the effectiveness of exercise for body weight reduction. Although this compensatory behavior is well documented, it is not known whether it follows a dose-response relationship according to the volume and intensity of exercise, as well as if it is affected by aerobic training.