CHRONIC UNPREDICTABLE STRESS PROTECT LPS-INDUCED LONG-TERM MEMORY IMPAIRMENT IN RATS.

Prolonged periods of stress may cause or exacerbate neuropsychiatric-related disorders. Stress activates the hypothalamic-pituitary-adrenal (HPA) axis, ultimately releasing glucocorticoid hormones (GCs), which activate mineralocorticoid (MR) and glucocorticoid (GR) receptors. These receptors are expressed in essential brain regions related to cognition, memory, and stress processing, such as the hippocampus (HP) and infralimbic prefrontal cortex (IL-mPFC). Neuroinflammation also plays a crucial role in developing neurological diseases and contributes to neurodegeneration and memory loss. However, the relationship between stress, inflammation, and memory processes remains poorly understood.