Anais da XXXVII Reunião Anual da FeSBE

Partial hepatectomy (PHx) is a surgical procedure of partial resection of the liver that is used to treat various conditions, such as liver tumors or advanced liver disease. The liver has a remarkable ability to regenerate itself so that the loss of functional tissue derived from resection induces hyperplasia and hypertrophy of liver cells so that the size, shape, and functional capacity of the organ are regained. During regeneration, adequate energy supply plays a crucial role, since the liver is a metabolically active organ and requires energy to sustain its cellular activities as well as the synthesis of new proteins, DNA replication, and other processes involved in tissue repair. However, PHx elevates the production of reactive oxygen species and consequently increases mitochondrial oxidative stress and reduces the rate of ATP synthesis. From this, β-hydroxy-β-methylbutyrate (HMB), a metabolite of the amino acid leucine used as a dietary supplement that has been pointed out by studies as an autophagic regulator, of proteosomal systems, and of mitochondrial biogenesis, stands out.