CHARACTERIZATION OF ISOLATED MITOCHONDRIA FRACTION OBTAINED FROM RAT LIVER: IMPLICATIONS TO MITOTHERAPY

Mitochondria are organelles associated with ATP production and also participate in several intracellular signaling pathways. In addition, free mitochondria are incorporated by structural cells and it’s acknowledged as a spontaneous event between healthy and damaged cells. In this way, isolated mitochondria may configure as a promising therapeutic target for diseases with metabolic defects. Thus, the adequate characterization of isolated mitochondria is fundamental, so that it can be incorporated into protocols of mitotherapy.